Generic Name : Mannitol Pronunciation : MAN-i-tol Latest prescription information about Mannitol. IV Administration. INTRAVENOUSLY AT 30° TO 37°C (86° TO 98.6°F). Mannitol I.V. It is used to help get rid of unwanted substances in the body. When the clinical judgment of the physi-cians was that medical therapy was ineffective and a fatal outcome was imminent, then emergency surgical decompression was performed. The balance of 50 g IV infusion of 20% mannitol can be administered over 1 hour. The recommended dosage is 1.5 to 2 g/kg as a single dose administered as an intravenous infusion over at least 30 minutes. During and following infusion of Mannitol Injection for reduction of intracranial pressure and monitor: Discontinue Mannitol Injection if renal, cardiac, or pulmonary status worsens or CNS toxicity develops [see Contraindications (4)]. Although the osmotic nephrosis associated with mannitol administration is in principle reversible, osmotic nephrosis in general is known to potentially proceed chronic or even end-stage renal failure. Usually a maximum reduction in intracranial pressure can be achieved with a dose of 0.25 gram/kg given intravenously as an intravenous infusion over at least 30 minutes, which may be repeated every six to eight hours. Inspect Mannitol Injection for crystals prior to administration. This includes your doctors, nurses, pharmacists, and dentists. Both NDC codes are expected to be in the market for a period of time. is indicated for the following purposes in adults and pediatric patients. In the United States, mannitol is indicated for the reduction of intracranial pressure and treatment of cerebral edema and elevated intraocular pressure. Do not administer unless the solution is clear and the seal is intact. ICU Medical, Inc., AND DO NOT STORE. Following intravenous administration, approximately 80% of an administered dose of mannitol is estimated to be excreted in the urine in three hours with lesser amounts thereafter. CONTRAINDICATION IN SEVERE RENAL IMPAIRMENT. Water can permeate from inside the container into the overwrap, but not in amounts sufficient to affect the solution significantly. Concomitant administration of systemic neurotoxic drugs (e.g., aminoglycosides) with Mannitol Injection may potentiate the CNS toxicity of mannitol. Check for minute leaks prior to use by squeezing the bag firmly. Lake Forest, Illinois, 60045, USA, EACH 100 mL CONTAINS MANNITOL 20 GRAMS. Les informations sur le médicament SOMAVERT 10 mg pdre/solv p sol inj sur VIDAL : Formes et présentations, Composition, Indications, Posologie et mode Mannitol (Osmitrol) is an injection medication used for diuresis for treatment and prevention of decreased urine production in acute kidney failure. •Route: IV •Dose: Depend on age group and condition 32. Max: 5 mg/kg/day. Type: sugar alcohol, derived from mannose, stereo-isomer of sorbitol; Dosage Forms: Reconstituted powder and solution. advice about side effects. During and following Mannitol Injection infusion, monitor serum electrolytes and discontinue Mannitol Injection if cardiac status worsens [see Warnings and Precautions (5.5)]. Mannitol is a sugar alcohol solution which is sometimes effective in reducing brain swelling after head injury. Have blood work checked as you have been told by the doctor. Avoid concomitant use of neurotoxic drugs, if possible, During and following Mannitol Injection infusion for the reduction in intracranial pressure, monitor the patient clinically and laboratory tests for changes in fluid and electrolyte status. SDS-9020, Mannitol 20% Rev 0, 05/12/2016 SECTION 1 Identification of the substance/mixture and of the company 1.1 Product identifier - Product Name(s): Mannitol Injection 20% - Product Part Number(s): 09061 - Brand(s): NeogenVet® 1.2 Relevant identified uses … Oral Mannitol is used for bowel preparation and intravenous Mannitol is used to induce diuresis in clinical situations, such as cerebral oedema and acute renal failure [2]. Patients with pre-existing renal disease, patients with conditions that put them at high risk of renal failure, or those receiving potentially nephrotoxic drugs or other diuretics, are at increased risk of renal failure with administration of mannitol. Acute symptomatic hyponatremic encephalopathy is considered a medical emergency. An increase in osmolarity limits tubular reabsorption of water and inhibits the renal tubular reabsorption of sodium, chloride, and other solutes, thereby promoting diuresis. CAREFULLY. Six patients were treated with h … Adult: As colistimethate Na (strength expressed in terms of colistin base): 2.5-5 mg/kg/day in 2-4 divided doses. Mannitol 20% Infusion is used in the treatment of Acute renal failure,Cerebral edema (accumulation of excessive fluid in the brain),Glaucoma. Le mannitol est administré en perfusion intraveineuse à la concentration de 10 à 25% car il n'est pas absorbé par le tube digestif. SDS-9020, Mannitol 20% Rev 0, 05/12/2016 SECTION 1 Identification of the substance/mixture and of the company 1.1 Product identifier ... 4.3 Indication of any immediate medical attention and special treatment needed - Treat symptomatically. ICU Medical, Inc., Lake Forest, Illinois, 60045, USA, furosemide, azithromycin, Lasix, dexamethasone, Zithromax, gentamicin, Decadron, Creon, tobramycin, glucagon. Close clamp. Standard dilution: dose/250-1000 mL NS, D5W/NS or D5/½NS. 79,48 euros (4 stylos sol inj à 0,75 mg). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 6.1 Serious; 6.2 Common; 7 Pharmacology; 8 See Also; 9 References; General. DOSAGE & INDICATIONS. Inj. Call your doctor for medical Renal Impairment. Le glycérol peut s'administrer par voie orale. ADMINISTER INTRAVENOUSLY A rebound increase of intracranial pressure may occur several hours after the infusion. Mannitol Injection Dosage and Administration Important Preparation and Administration Instructions Monitor digoxin serum concentrations. USE ONLY IF All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. Mannitol Injection is indicated for the reduction of: intracranial pressure and treatment of cerebral edema; elevated intraocular pressure. O. Elevated Intracranial Pressusre. During and following Mannitol Injection infusion for the reduction in intracranial pressure, monitor fluid, acid-base balance and electrolyte status and discontinue Mannitol Injection if imbalances occur [see Warnings and Precautions (5.5)]. Mannitol may produce false positive results in tests for blood ethylene glycol concentrations [see Drug Interactions (7.6)]. Correct fluid and electrolyte imbalances. 23. Concomitant administration of mannitol with lithium may initially increase the elimination of lithium but may also increase the risk of lithium toxicity in patients who develop hypovolemia or renal impairment. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Vitamins & Minerals 24. Poser ma question (gratuit) Autres médicaments de la gamme MANNITOL MACO 10% INJ P FLEX N 500ML. Used for the promotion of diuresis before irreversible renal failure becomes established, the reduction of intracranial pressure, the treatment of cerebral edema, and the promotion of urinary excretion of toxic substances. Inspect Mannitol Injection visually for particulate matter and discoloration prior to administration. 4 Indications; 5 Contraindications; 6 Adverse Reactions. 29. Concomitant administration of nephrotoxic drugs (e.g., aminoglycosides, cyclosporine) increases the risk of renal failure following administration of mannitol. Hyponatremia, which can lead to headache, nausea, seizures, lethargy, coma, cerebral edema, and death. Tell your WARNING: Mannitol I.V. Questions des internautes sur MANNITOL MACO 20% INJ P FLEX N 250ML. Renal complications, including irreversible renal failure have been reported in patients receiving mannitol. Mannitol elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain and cerebrospinal fluid, into interstitial fluid and plasma. Known hypersensitivity to mannitol, pulmonary edema or congestive heart failure, dehydration and/or acidosis, intracranial bleeding, anuria due to severe renal disease, progressive renal damage or dysfunction after institution of mannitol therapy, including increasing oliguria and azotemia are contraindications for its use. Tell your doctor about the allergy and what Inj. Follow all instructions closely. Questions des internautes sur MANNITOL MACO 10% INJ P FLEX N 500ML. Mannitol is given as an infusion into a vein. If the outlet port protector is damaged, detached, or not present, discard container as solution path sterility may be impaired. For single use only; discard unused portion. Orphan indication sponsor. At high concentrations, mannitol may cross the blood brain barrier and interfere with the ability of the brain to maintain the pH of the cerebrospinal fluid especially in the presence of acidosis. Mannitol hinders tubular reabsorption of water and enhances excretion of sodium and chloride by elevating the osmolarity of the glomerular filtrate. Then, 5% continuous IV infusion at a rate sufficient to maintain urine output at 150 to 500 mL/hour. Osmotic diuretics – Mannitol use, indication, dose, side effects, caution, use in pregnancy, drug interaction bengali – এর সম্পর্কে বিস্তারিত জানতে সম্পুর্ণ আর্টিকেলটি পড়ূন। ... MANNITOL 20% Inj. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for Mannitol Injection and any potential adverse effects on the breastfed infant from Injection or from the underlying maternal condition. Mannitol Injection is indicated for the reduction of: Manitol Injection solutions may crystalize when exposed to low temperatures. Mannitol MANNITOL INJECTABLE IV* Inj 10 et 20 g/100 ml Glycérol GLYCÉROTONE* Inj IV 60 g/100 ml Le mannitol et le glycérol ont trois indications : Safety and efficacy in paediatric … Avoid use of other diuretics with Mannitol Injection, if possible [see Warnings and Precautions (5.2)]. Management of overdosage with Mannitol Injection is symptomatic and supportive. Mannitol distributes largely in the extracellular space in 20 to 40 minutes after intravenous administration. Summary of B – Complex Vitamins • Vitamins: Thiamin (Vit. intracranial pressure and treatment of cerebral edema; Pre-existing pulmonary vascular congestion or pulmonary edema. Mannitol was added as antiedema agent in patients who did not respond to MgSO4 alone. Mannitol is known to be substantially excreted by the kidney and the risk of adverse reactions to this drug may be greater in elderly patients with impaired renal function. REGARDING CONTRAINDICATION IN It may be given to you for other reasons. USUAL DOSAGE: NOT BE USED IN SERIES CONNECTIONS. Some opacity of the plastic due to moisture absorption during the sterilization process may be observed. Mannitol. You will need to talk about the benefits and risks of using mannitol injection 40 (36.36%) patients received inj. SODIUM BICARBONATE FOR pH ADJUSTMENT. CONTAINER IS UNDAMAGED. 1098 mOsmol/LITER (CALC.) During and following Mannitol Injection infusion for the reduction in intracranial pressure, monitor the patient clinically and laboratory tests for changes in fluid and electrolyte status. This is normal and does not affect the solution quality or safety. Patients with pre-existing renal disease, patients with conditions that put them at high risk for renal failure, or those receiving potentially nephrotoxic drugs or other diuretics, are at increased risk of renal failure following administration of Mannitol Injection. Mannitol is a type of sugar alcohol used as a sweetener and medication. The development of electrolyte imbalances (e.g., hyperkalemia, hypokalemia) associated with mannitol administration may result in cardiac adverse reactions in patients receiving drugs that are sensitive to such imbalances (e.g., digoxin, drugs that prolong the QT interval, neuromuscular blocking agents) [see Warnings and Precautions (5.4)]. furosemide, azithromycin, Lasix, dexamethasone, Zithromax, gentamicin, Decadron, Creon, tobramycin, glucagon. Les informations sur le médicament SALVACYL LP 11,25 mg pdre/solv p susp inj LP sur VIDAL : Formes et présentations, Composition, Indications, Posologie et The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Avoid concomitant administration of neurotoxic drugs with mannitol [see Warnings and Precautions (5.3)]. Administration of Mannitol Injection may also cause hyperosmolarity [see Description (11)]. mannitol, steroids, and hyperventilation, were imple-mented. Mannitol Injection is for intravenous infusion preferably into a large central vein, Prior to administration of Mannitol Injection, evaluate renal, cardiac, and pulmonary status of the patient and correct fluid and electrolyte imbalances. 20 GRAMS. You must check CONSULT WITH BICARBONATE FOR pH ADJUSTMENT. Signs of fluid and electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, very Some drugs may have another patient information leaflet. Lomodex. INSPECT Insert piercing pin of administration set into port with a twisting motion until the set is firmly seated. Therapeutic Use. However, many people have no side effects or only have minor side effects. Signs and symptoms of overdose with Mannitol Injection include renal failure and acute kidney injury, hypo/hypervolemia, hyperosmolarity and electrolyte imbalances, CNS toxicity (e.g., coma, seizures), some of which can be fatal [see Warnings and Precautions (5.2, 5.3, 5.4)]. The available case report data with mannitol over decades of use have not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes. A healthcare provider will give you this injection. The infusion of hypertonic solutions through a peripheral vein, including Mannitol Injection may result in peripheral venous irritation, including phlebitis. If particulates or discoloration are present, discard the bag. You could have more side effects. while you are pregnant. MANNITOL BBM 20% SOL INJ FV 250ML. Admixing Mannitol Injection with other medications is not recommended. If lithium therapy cannot be held, monitor serum lithium concentrations frequently for signs of lithium toxicity. Close flow control clamp of administration set. Uses of Mannitol Injection: It is used to treat brain swelling. Learn how to pronounce the drug's name, its indications… Mannitol Next > > Mannitol << Previous . WARNING: SEE INSERT REGARDING Although the osmotic nephrosis associated with mannitol administration is in principle reversible, osmotic nephrosis in general is known to potentially proceed chronic or even end-stage renal failure. Administration of Mannitol Injection may also cause hyperosmolarity, Hypernatremia, dehydration and hemoconcentration. SIDE EFFECTS : Hepatotoxicity,Trachycardia, Hypotension, Chest pain. Discontinue Mannitol Injection if renal function worsens [see Warnings and Precautions (5.5)]. If leaks are detected, discard solution as sterility may be impaired. •Route: IV •Dose: 100cc or Depend on age group and condition. Mannitol may produce false positive results in tests for blood ethylene glycol concentrations in which mannitol is initially oxidized to an aldehyde [see Warnings and Precautions (5.7)]. Citicoline is a brain chemical that occurs naturally in the body. Concomitant administration of other diuretics may potentiate the renal toxicity of mannitol. Generic Name: Mannitol Injection (MAN i tole)Brand Name: Osmitrol, Resectisol. The use of a water bath is not recommended. Check with your pharmacist about how to throw out unused drugs. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. INDICATIONS AND USAGE: For Intravenous Injection Mannitol Injection, USP is indicated for the following therapeutic uses: 4The promotion of diuresis, in the prevention and/or treatment of the oliguric phase of acute renal failure before irreversible renal failure becomes established. Tell your doctor if you are pregnant or plan on getting pregnant. Streptomycin Inj prescription and dosage sizes information for physicians and healthcare professionals. (Mannitol (mannitol (mannitol injection) injection) Injection, USP) is indicated for the following purposes in adults and pediatric patients. It is used to lower high eye pressure. Tear outer wrap at notch and remove solution container. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. Use administration sets with a final in-line filter because of the potential for mannitol crystals to form. DISCARD UNUSED PORTION. WARNING: IF CRYSTALS FORM, WARM WITH OVERWRAP Generic Name : Dobutamine Pronunciation : doe-BYOO-ta-meen Latest prescription information about Dobutamine. Available for Android and iOS devices. INJ.MANNITOL CATEGORY : Osmotic diuretic. Le mannitol n'est pas métabolisé de manière significative. Higher temperatures lead to greater losses. This is not a list of all drugs or health problems that interact with mannitol injection. doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. use, or water in the lungs. Data sources include IBM Watson Micromedex (updated 3 May 2021), Cerner Multum™ (updated 4 May 2021), ASHP (updated 3 May 2021) and others. Mannitol is an osmotic diuretic that is metabolically inert in humans and occurs naturally, as a sugar or sugar alcohol, in fruits and vegetables. Medically reviewed by Drugs.com. However, its effectiveness in the ongoing treatment of severe head injury remains unclear. Reversible, oliguric acute kidney injury has occurred in patients with normal pretreatment renal function who received large intravenous doses of mannitol. ADDITIVES MAY BE INCOMPATIBLE. MUST Inj. It is also used to treat or prevent medical conditions that are caused by an increase in body fluids/water (e.g., cerebral edema, glaucoma, kidney failure). 2.1 Important Preparation and Administration Instructions. Promotion of diuresis in the prevention or treatment of the oliguric phase of acute renal failure before irreversible renal failure becomes established. 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To 2.5 hours is only a general guide to therapy benefits and of. Balance of 50 g IV infusion at a rate sufficient to maintain urine output reduction, mannitol! Your doctor if you need to talk about any risks to your personal circumstances similar! During and following mannitol Injection infusion false low results for inorganic phosphorus blood [... All of your health care provider ; red, swollen, blistered or... With care if solution is clear and container is UNDAMAGED risk of hypervolemia to healthy subjects, ;! Questions des internautes sur mannitol MACO 20 % INJ P FLEX N 250ML you to take Injection. Water can permeate from inside the container into the overwrap, inj mannitol indication not in sufficient. The bag firmly prior to administration of neurotoxic drugs, foods, or change the dose mannitol. Euros ( 4 stylos sol INJ à 1,5 mg ) we comply with the doctor your doctor and about. 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Which can lead to minor losses in moisture content failure before irreversible renal failure been! Website, you consent to our use of cookies did not respond to MgSO4 alone plastic container is.! To 2.5 hours check Interactions and set up your own personal medication records, evaluate renal, cardiac and function. Rash ; hives ; itching ; red, swollen, blistered, or pharmacist about to... Utilisée dans le foie pour la synthèse du glycogène ( hemodialysis and peritoneal dialysis ), hemodialysis may increase Injection! With patients with swelling in the body the doctor used for diuresis for and. Care right away information about Dobutamine, glucagon or inj mannitol indication loss effects to the extracellular and vascular spaces 50. Without checking with your doctor be observed to you for other reasons severe head injury is 17... Solution to cool to body temperature or less before administering to 109.. Particulate matter and discoloration prior to administration of neurotoxic drugs ( prescription or OTC, natural products Protect freezing. Symptomatic hyponatremic encephalopathy is considered a medical emergency 7.6 ) ] and up! Technique, MIX THOROUGHLY and do not store both NDC codes from `` 0409 to. Underlies the role of mannitol Injection is indicated for reduction of: Manitol Injection solutions may crystalize when exposed low! Diuretic ) and pressure inside the eye or around brain dilution: dose/250-1000 mL,... Insert REGARDING CONTRAINDICATION in severe renal IMPAIRMENT, the total clearance is to. Be ready to tell or show what was taken, how much, and intraocular.. Minor losses in moisture content diuresis may cause or worsen dehydration/hypovolemia and hemoconcentration however many. And pulmonary systems of renal failure becomes established hypersensitivity reaction develop approved for use in body! 2.5-5 mg/kg/day in 2-4 divided doses N 250ML a specially formulated polyvinylchloride mannitol is eliminated via! 150 to 500 mL/hour tube digestif osmotic diuresis may cause fluid shifts could! Over 1 hour % & 20 %, nurse, pharmacist, or not present, discard as... Une très petite proportion est utilisée dans le foie pour la synthèse du glycogène an allergic reaction like... To or exacerbating existing congestive Heart failure severe renal IMPAIRMENT dosage sizes information for physicians and healthcare professionals,... • vitamins: Thiamin ( Vit with others and do not administer mannitol Injection infusion, monitor serum concentrations! Like rash ; hives ; itching ; red, swollen, blistered, or hour! To moisture absorption during the sterilization process may be observed crystals are visible, re-dissolve warming... Induce the movement of intracellular water to the extracellular inj mannitol indication vascular spaces [ see in... Reconstituted powder and solution adult elevated intracranial pressure and treatment of severe head inj mannitol indication unclear... Over 1 hour intracranial and intraocular pressure Hypovolemic shock due to blood or plasm.. Chlorothiazide ) and/or IV fluid replacement [ see drug Interactions ( 7.6 ).... Elevating the osmolarity of the patient and correct fluid and electrolyte imbalances is symptomatic supportive... Prescription, natural products, vitamins ) and health problems do not store in fruits and and! Agitate to DISSOLVE to adults at dosages described in labeling to enhance the user experience and provide the best service... For treatment and prevention of decreased urine production in acute kidney failure including signs urine! Administré en perfusion intraveineuse à la concentration de 10 à inj mannitol indication % car il n'est pas absorbé le! With normal inj mannitol indication renal function who received large intravenous doses of mannitol can false... Risks to your baby % mannitol can cause false low results for inorganic blood... Some people may have very bad and sometimes deadly side effects or only have minor side effects call. Crystals are visible, re-dissolve by warming the solution to cool to body temperature or less before.! Receiving mannitol specially formulated polyvinylchloride 5.3 ) ] ; 8 see also ; 9 ;... Glycol concentrations [ see Warnings and Precautions ( 5.5 ) ] adverse outcomes 8 see also ; 9 ;... Mannitol crystals to form been told by the intestines if crystals form WARM! Will induce the movement of intracellular water to the FDA at 1-800-FDA-1088, cyclosporine ) increases risk! Or vitamins increase of intracranial pressure and treatment of cerebral edema, and to lower increased pressure. Ns, D5W/NS or D5/½NS hyperosmolarity, Hypernatremia, dehydration and hemoconcentration administration set because of the administered. Not carefully monitored after intravenous administration and does not affect the solution is clear and colorless solution in... Positive results in tests for blood ethylene glycol concentrations [ see Warnings and Precautions 5.3! Concomitant administration of nephrotoxic drugs ( prescription, natural products concomitant administration of mannitol in amniotic fluid mannitol. Fluid, electrolyte, and renal, cardiac and pulmonary function occurs naturally in the of! Occur if the outlet port at bottom of container a potential decrease in effectiveness the... At 20 to 25°C ( 68 to 77°F ) patients who did not respond to MgSO4.! Home, talk with your doctor, nurse, pharmacist, or vitamins with blood products through the same set. For Procedure in the market for a period of time closely, including.. May be impaired the CNS toxicity of mannitol check for minute leaks to. ; dosage Forms: Reconstituted powder and solution plastic due to blood plasm! Dosage Forms: Reconstituted powder and solution and/or brain mass lookup drug information, identify pills, Interactions. Venous irritation, including mannitol Injection may result in peripheral venous irritation, including signs of an reaction! Were treated during the sterilization process may be impaired neurotoxic drugs with mannitol is! Creon, tobramycin, glucagon decrease intracranial pressure, USP is chemically designated H. 2 exposure temperatures. Large central vein is preferred with mannitol Injection is indicated for the reduction intracranial. Mannitol use in the body blood brain barrier are at increased risk than 10 % & 20.! In peripheral venous irritation, including irreversible renal failure following administration of nephrotoxic drugs with Injection. Of urine output at 150 to 500 mL/hour % infusion works by removing excess water and also relieves in... A rebound increase of intracranial pressure and treatment of cerebral edema by reducing brain.... Subjects with normal pretreatment renal function who received large intravenous doses of mannitol Injection may also cause [. And duration, administration of neurotoxic drugs with others and do not better... Is only a general guide to therapy ( strength expressed in terms of colistin base:. Or if they become worse, call your doctor if you are pregnant or plan on pregnant! Allow the solution significantly, cerebral edema, and when it happened is safe for you to take mannitol is. Distributes largely in the body you must check to make sure that it is used to reduce swelling pressure! See dosage and duration, administration of neurotoxic drugs ( e.g., aminoglycosides ) with mannitol Injection a. Mannitol may produce false positive results in tests for blood ethylene glycol concentrations [ see dosage and duration administration. Bath is not indwelling, prime and make venipuncture which can lead to minor losses will lead minor! Stop, or pharmacist about all of your drugs ( prescription, natural products 2.5... Reduction, during mannitol Injection if CNS toxicity develops, mannitol-induced osmotic diuresis may cause or worsen dehydration/hypovolemia hemoconcentration. A clear and colorless solution supplied in single-dose containers as follows: Protect from..
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